The experience of cancer is challenging for both patients and their family caregivers. Patients are confronted with the side effects of treatment, emotional distress from their diagnosis and treatment, and the effects of cancer on their occupational functioning and economic well-being. Family caregivers share in this experience and provide vital support to the individual diagnosed with cancer. Caregiving can be rewarding for many family members and friends; however, caregiving can also be stressful and increase the risk of depression and occupational and economic challenges. This can be compounded when the family, community, or health care system has limited resources. The goal of this symposium will be to provide the delegates with a diverse set of lectures from around the world that will discuss the challenges faced by patients and family caregivers in the context of cancer. The learning objectives will include a better understanding of: (1) the interdependence between stress and sleep quality between patient and caregiver dyads in the United States, (2) the gaps in supportive care for patients and caregivers from Turkey, (3) the role of family caregiver hardiness in resilience and care of their loved one with cancer in sub-Saharan Africa, (4) the unmet needs of caregivers of cancer patients in south west Nigeria, (5) the effects of social determinants of health on symptom burden and health outcomes of patients with cancer and their family caregivers in the United States, and (6) the special role of adult children as caregivers of a parent with cancer in Denmark, and (7) meaning-making experiences of Australian individuals with cancer and their family caregivers. Delegates will gain a global perspective of the journey of patients diagnosed with cancer and their family caregivers, in low, middle and high resource communities.