Objectives: Public stigma associated with cancer is a pervasive issue, potentially impeding survivors’ societal participation. This study aimed to identify predictors of prosocial behaviours towards cancer survivors. Sample and setting: Potential participants (N=2,988) were recruited from a marketing company in Japan. A nationwide survey was completed by 1,076 voluntary adults with no history of cancer; their mean age was 47.2 years (SD=11.4) and 36.4% were women. A secondary analysis of previously collected research data was conducted. Procedures: Validated measures were used to assess stereotypes (of cancer, of survivors’ social lives and cancer attributions), emotional reactions to others’ cancer diagnoses, empathic and negative coping, interpersonal communication, helping intentions, cancer knowledge, and demographic information. Structural equation modelling was used to examine the hypothesised model grounded in stigma attribution and stress coping theories. Prosocial behaviours such as interpersonal communication and helping intentions were endogenous latent variables, and stereotypes were exogenous latent variables. Emotional reactions and empathic and negative coping were mediators. Control variables included cancer knowledge, gender, and familiarity with cancer survivors. Results: The hypothesised model demonstrated good fit indices (comparative fit index=1.00; root mean square error of approximation=0.00). Cancer attributions (β=. 354, p<.05), and stereotypes of cancer survivors’ social lives (β=.147, p<.05) were significantly associated with emotional reactions, which were significantly associated with empathic coping (β=-.989, p<.05) and negative coping (β=.260, p<.05). Empathic coping was associated with interpersonal communication (β=-.729, p<.05) and helping intentions (β=-.740, p<.05). Negative coping was associated with interpersonal communication (β=.478, p<.05) but not helping intentions. All control variables were significantly associated with prosocial behaviours. Conclusion and clinical implications: Strengthening empathic coping may promote prosocial behaviours towards survivors, despite stereotype biases. Interventions targeting empathic skills among the public are vital for reducing stigma and facilitating survivors’ societal integration.