Background and Aim. With ongoing advances in cancer treatment, people with cancer may be increasingly able and want to work while undergoing treatment, however, the process of continuing or returning to work is highly influenced by individuals’ unique life situation which may change over time. When considering whether to work or not work, people with cancer may be influenced by their perceived ability to work (e.g., considering impact from treatment side effects), whether they have opportunities to work (e.g., depending on the nature of support by their healthcare provider and workplace) and their motivations for working (e.g., to help maintain financial security). By applying the Ability-Motivation-Opportunity (AMO) framework, our research explored interactions between the AMO components and the relationship with desire to work and working during treatment. Method. 190 people with cancer who were receiving treatment or were diagnosed within the past 3 years completed a survey measuring perspectives and experiences about working with cancer. Results. Hierarchical linear regression revealed that desire to work was significantly predicted by perceived motivation (β = .62, p<.001) with a significant three-way interaction between ability, motivation and opportunity (β = -.16, p =.04), explaining 54% of variance. Logistic regression revealed that working during treatment was significantly predicted by lower perceived ability (β = -1.23, p<.001), with significant two-way interactions for ability and motivation (β = .51, p = .02), motivation and opportunity (β = 0.51, p =.004) and ability and opportunity (β = -0.58, p =.01), however, a significant three-way interaction was not observed. Implications. Our preliminary findings highlight the importance of integrated workplace and health system supports that help align and promote ability, motivation, and opportunity, enabling desire to work to translate into meaningful work participation.