Objectives: The study objectives were to explore the experiences of engaging in intravenous (IV) insertions/venipuncture among Indian healthcare providers (HCP; oncologists and nurses), patients, and their caregivers. Sample and setting: Using a mixed methods approach, first, qualitative interviews were conducted to understand the lived experiences of administering/receiving venipunctures among HCPs (n=21; females=8; mean age=33 years), patients (n=5; female= 1; mean age=49.6 years), and their caregivers (n=6; females=4; mean age=42.3 years) at a cancer hospital in India. Then, a survey examining the common issues/concerns of IV insertions among HCPs (n=171; females=162; mean age=29.8 years), patients (n=154; females=108; mean age=46 years), and caregivers (n=158; females=57; mean age=61.5 years) was administered at the same cancer hospital. Procedure: For the qualitative study, individual, audio-recorded, semi-structured interviews were conducted with the participants, and these were analyzed using qualitative content analysis. For the quantitative study, survey questions were administered to the participants which were generated from the qualitative interviews as well as the available literature on experiences of medical errors in venipunctures. Quantitative data was analyzed using Multivariate Analysis of Variance (MANOVA). Results: The qualitative study revealed limited visibility of the veins of pediatric and geriatric patients, medical comorbidities, structural barriers, and high patient volume as the most commonly experienced challenges for performing cannulation. The quantitative results showed that the nurses reported successfully cannulating on their first try whereas patients reported a high incidence of multiple venipunctures. Patient counseling and empathic communication during the procedure were reported to effectively mitigate concerns and reduce emotional distress across the sample. Conclusion and clinical implications: The findings demonstrated that, in India, patients accepted procedural, repetitive pain as part of the cancer journey. The study underscores the need for new technology to aid in pain relief (e.g., 3D vein viewer) in Indian cancer settings.