Objective: To explore the influencing factors related to axillary sentinel lymph node metastasis in invasive breast cancer, and to provide reference factors for preoperative prediction of axillary sentinel lymph node metastasis in breast cancer. Methods: The clinicopathological data and blood indexes of 200 breast cancer patients admitted to Gansu Maternal and Child Health Hospital (Gansu Central Hospital) from December 2019 to November 2022 were retrospectively analyzed, and the risk factors affecting axillary sentinel lymph node metastasis were analyzed by multivariate analysis. Results: Among the 200 breast cancer patients, 124 had axillary sentinel lymph node metastasis and 76 had no metastasis. There were significant differences between metastatic group and non-metastatic group in Ki-67, AR, SII, and NLR (P < 0.05); while age, menstrual status, tumor size, histological grade, vascular tumor thrombus, molecular classification, HER-2, EGFR, CK5/6, E-cadherin, p53, MRR, RPR, PLR, D-Dimer, FIB, TC, and HDL-C between the two groups were not statistically significant (P > 0.05). The results of multivariate analysis showed that AR (P = 0.010, 95% CI = 1.330-7.983) and NLR (P = 0.046, 95% CI = 1.013-4.061) were independent risk factors for axillary sentinel lymph node metastasis. Conclusion: AR and NLR are independent risk factors for axillary sentinel lymph node metastasis in breast cancer, and can be used as predictors of axillary sentinel lymph node metastasis in breast cancer.