Poster Presentation 2025 Joint Meeting of the COSA ASM and IPOS Congress

Oncofertility information interventions in cancer patients: A systematic review and meta-analysis (126133)

Mengyan Hao 1 , Huan Li 2 , Dandan Zhang 1 , Ying Huang 1 , Ting Liu 1
  1. School of Nursing, Sun Yat-sen University, Guangzhou, Guangdong, China
  2. Department of Thyroid and Breast Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

 

Objectives:

The fertility issue among cancer patients has received growing attention. This study aims to systematically synthesize and evaluate the impact of oncofertility information interventions in cancer patients.

Methods:

A comprehensive search was conducted in PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library from inception to May 29, 2025. Randomized controlled trials using oncofertility information interventions among cancer patients were included. Two authors independently screened the eligible studies, assessed the quality of studies, and extracted data. The risk of bias was evaluated using version 2 of the Cochrane risk-of-bias tool for randomised trials (RoB 2). The certainty of the evidence was evaluated using the GRADE system. Meta-analysis was conducted using R software (v 4.4.3).

Results:

A total of 10 studies were included in this systematic review, involving 995 participants, with 9 studies included in the meta-analysis. The pooled analysis showed that oncofertility information interventions could significantly improve patients' reproductive knowledge (SMD=0.37, 95% CI 0.01-0.72, p=0.0414; moderate quality of evidence), reducing reproductive concerns (MD=-17.53, 95% CI -34.64--0.41, p=0.0448; moderate quality of evidence) and decisional conflict (MD=-5.83, 95% CI -10.49--1.17, p = 0.0142; high quality of evidence). Subgroup analysis indicated that the non-Asian group, multiple types of cancer, moderate to high-intensity and online interventions were more effective for reproductive knowledge(p<0.05). The influence of patients' gender on the effectiveness of oncofertility information interventions was not determined.

Conclusion and clinical implications:

This meta-analysis provides low to moderate quality evidence for the role of oncofertility information interventions in enhancing reproductive knowledge, reducing reproductive concerns and decisional conflict among cancer patients. To identify the most effective components, more rigorous research designs and more detailed descriptions of intervention measures are needed.