Poster Presentation 2025 Joint Meeting of the COSA ASM and IPOS Congress

Photobiomodulation therapy for post-radiation fibrosis in head and neck cancer: A series of case reports (126436)

Purpose:

  1. Understand the Mechanistic Basis of Photobiomodulation in Treating Post-Radiation Fibrosis in patients with head and neck cancer.
  2. Critically Evaluate the Therapeutic Outcomes of PBM Using MLS Laser Devices in Case Reports.
  3. Explore the broader implications of MLS Laser Therapy as a non-invasive treatment modality for Oncological Rehabilitation.

Background: Post-radiation fibrosis remains a challenging consequence for survivors of head and neck cancer (HNC), often leading to a decline in functional abilities and life quality.

Multiwave Locked System (MLS) Laser Therapy has recently been investigated as a therapeutic intervention for PRF with potential benefits.

Methods: Case reports for 4 patients with a history of HNC who developed PRF following radiation therapy and received MLS Laser Therapy are presented.

Detailed case descriptions, including treatment parameters, frequency, and duration, were documented. Outcomes were assessed through clinical measures of fibrosis severity, range of motion, pain levels, and functional status involving speech and swallowing. Quality-of-life changes were evaluated.

The PBM parameters were as follows: wavelength (808nm and 905nm), power, frequency, with an energy dose of 3.99 Joules/cm² per session, administered over the treatment area.

Results: All patients demonstrated varying degrees of improvement in fibrosis and associated symptoms, including reduced Lymphoedema symptoms.

Results showed a significant improvement in fibrosis symptoms, including reduced stiffness, increased range of motion, and decreased pain. Statistical analysis was conducted to evaluate the treatment outcomes, using pre- and post-treatment assessments of fibrosis symptoms and quality of life measures.

Conclusion: These case reports contribute to the emerging evidence that MLS Laser Therapy may be a safe and effective treatment for PRF in HNC patients, offering pain relief and functional improvements. While these reports highlight the therapeutic potential, they also underscore the need for further research through larger-scale studies to establish standardized treatment protocols and long-term efficacy of MLS Laser Therapy for PRF.